14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro | Zendy

Mao Xie | Zendy; Yi Xiang | Zendy; Renjun Wang | Zendy; LiSheng Wang | Zendy; Guangyao He | Zendy; Meichan Zhu | Zendy; Chenglin Qi | Zendy; Yikang Liu | Zendy; Ye Yu | Zendy; Songhua Tan | Zendy; Anzhou Tang | Zendy

Open Access

14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways <b><i>in Vitro</i></b>

Author(s) -

Mao Xie,

Yi Xiang,

Renjun Wang,

LiSheng Wang,

Guangyao He,

Meichan Zhu,

Chenglin Qi,

Yikang Liu,

Ye Yu,

Songhua Tan,

Anzhou Tang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358712

Subject(s) - matrine , protein kinase b , pi3k/akt/mtor pathway , mapk/erk pathway , nasopharyngeal carcinoma , apoptosis , kinase , mtt assay , cancer research , chemistry , cell growth , microbiology and biotechnology , protein kinase a , p38 mitogen activated protein kinases , signal transduction , biology , medicine , biochemistry , chromatography , radiation therapy

Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with the highest incidence in South China. Previous studies have proved that matrine, a main alkaloid isolated from Sophora flavescens Ait, has antitumor activity against NPC. However, the effect is not so pronounced and the underlying mechanism remains largely unclear. Here we investigated whether 14-thienyl methylene matrine (YYJ18) that was derived from matrine could exert more effective suppression activity on NPC, along with the underlying mechanism.

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