Hypoxia Induces Autophagy of Bone Marrow-Derived Mesenchymal Stem Cells via Activation of ERK1/2 | Zendy

Junfang Wu | Zendy; Jie Niu | Zendy; Xiaopeng Li | Zendy; Yonghai Li | Zendy; Xianwei Wang | Zendy; Juntang Lin | Zendy; Fenxi Zhang | Zendy

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Hypoxia Induces Autophagy of Bone Marrow-Derived Mesenchymal Stem Cells via Activation of ERK1/2

Author(s) -

Junfang Wu,

Jie Niu,

Xiaopeng Li,

Yonghai Li,

Xianwei Wang,

Juntang Lin,

Fenxi Zhang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358711

Subject(s) - autophagy , mesenchymal stem cell , hypoxia (environmental) , microbiology and biotechnology , bone marrow , stem cell , chemistry , biology , immunology , apoptosis , biochemistry , oxygen , organic chemistry

Bone marrow-derived mesenchymal stem cells (bmMSCs) are the most promising seed cells for cell transplant therapy. Hypoxia is a known stimulus of autophagy. Recent studies showed that hypoxia promotes autophagy of human placental chorionic plate-derived mesenchymal stem cells (CP-MSCs). However, whether hypoxia affects autophagy of bmMSCs has not been examined. The goal of this study was to investigate the effect of hypoxia on autophagy of mouse bmMSCs and the underlying mechanisms.

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