Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants | Zendy

Jana Patková | Zendy; Michal Anděl | Zendy; Ján Trnka | Zendy

Open Access

Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants

Author(s) -

Jana Patková,

Michal Anděl,

Ján Trnka

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358709

Subject(s) - mitochondrion , myogenesis , myocyte , programmed cell death , mitochondrial ros , biology , mitochondrial dna , respiration , microbiology and biotechnology , skeletal muscle , c2c12 , biochemistry , apoptosis , endocrinology , anatomy , gene

Deleterious effects of saturated fatty acids in skeletal muscle cells are well known but their impact on mitochondrial respiration has not been well studied. Mitochondrial oxidative damage has been implicated to play a role in their effect. The purpose of this study was to evaluate viability, mtDNA integrity and mitochondrial respiration in C2C12 myoblasts and myotubes exposed to palmitate and to test the effect of mitochondria-targeted antioxidants MitoQ and MitoTEMPOL in preventing palmitate-induced damage.

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