Expression of the Transcription Factor Egr-1 in Pancreatic Acinar Cells Following Stimulation of Cholecystokinin or Gαq-Coupled Designer Receptors | Zendy

Anke Kaufmann | Zendy; Oliver G. Rößler | Zendy; Gerald Thiel | Zendy

Open Access

Expression of the Transcription Factor Egr-1 in Pancreatic Acinar Cells Following Stimulation of Cholecystokinin or Gαq-Coupled Designer Receptors

Author(s) -

Anke Kaufmann,

Oliver G. Rößler,

Gerald Thiel

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358707

Subject(s) - cholecystokinin , stimulation , transcription factor , cholecystokinin b receptor , receptor , cholecystokinin receptor , endocrinology , medicine , microbiology and biotechnology , chemistry , biology , gene , biochemistry

BACKGOUND/AIMS: The injection of cerulein, an analogue of the pancreatic secretagogue cholecystokinin (CCK), induces acute pancreatitis in mice that is accompanied by the synthesis of the transcription factor Egr-1. The signaling cascade that connects cerulein stimulation with enhanced Egr-1 biosynthesis was analyzed.

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