Green Tea Polyphenol Epigallocatechin-3-Gallate Inhibits TNF-a-Induced Production of Monocyte Chemoattractant Protein-1 in Human Umbilical Vein Endothelial Cells | Zendy

ZeMu Wang | Zendy; Wei Gao | Zendy; Hao Wang | Zendy; Di Zhao | Zendy; Zhenlin Nie | Zendy; JianQuan Shi | Zendy; Shan Zhao | Zendy; Xiang Lü | Zendy; Liansheng Wang | Zendy; Zhijian Yang | Zendy

Open Access

Green Tea Polyphenol Epigallocatechin-3-Gallate Inhibits TNF-a-Induced Production of Monocyte Chemoattractant Protein-1 in Human Umbilical Vein Endothelial Cells

Author(s) -

ZeMu Wang,

Wei Gao,

Hao Wang,

Di Zhao,

Zhenlin Nie,

JianQuan Shi,

Shan Zhao,

Xiang Lü,

Liansheng Wang,

Zhijian Yang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358702

Subject(s) - umbilical vein , monocyte , tumor necrosis factor alpha , epigallocatechin gallate , western blot , chemistry , microbiology and biotechnology , pharmacology , in vitro , biochemistry , polyphenol , medicine , biology , immunology , gene , antioxidant

Epigallocatechin-3-gallate (EGCG), a major catechin found in green tea, displays a variety of pharmacological properties and recently received attention as a prospective dietary intervention in cardiovascular diseases (CVD). This study was conducted to test the hypothesis that EGCG was able to inhibit tumor necrosis factor-α (TNF-α)-induced production of monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) and investigated the underlying molecular mechanisms.

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