Effect of PIP3 on Adhesion Molecules and Adhesion of THP-1 Monocytes to HUVEC Treated with High Glucose | Zendy

Prasenjit Manna | Zendy; Sushil K. Jain | Zendy

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Effect of PIP3 on Adhesion Molecules and Adhesion of THP-1 Monocytes to HUVEC Treated with High Glucose

Author(s) -

Prasenjit Manna,

Sushil K. Jain

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358688

Subject(s) - intercellular adhesion molecule 1 , cell adhesion molecule , microbiology and biotechnology , monocyte , adhesion , cell adhesion , intercellular adhesion molecule , downregulation and upregulation , chemistry , umbilical vein , thp1 cell line , icam 1 , lymphocyte function associated antigen 1 , endothelial stem cell , biology , immunology , biochemistry , cell culture , in vitro , organic chemistry , gene , genetics

Phosphatidylinositol-3,4,5-triphosphate (PIP3), a well-known lipid second messenger, plays a key role in insulin signaling and glucose homeostasis. Using human umbilical vein endothelial cells (HUVEC) and THP-1 monocytes, we tested the hypothesis that PIP3 can downregulate adhesion molecules and monocyte adhesion to endothelial cells.

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