GABA and Topiramate Inhibit the Formation of Human Macrophage-Derived Foam Cells by Modulating Cholesterol-Metabolism-Associated Molecules | Zendy

Yongqiang Yang | Zendy; Yi-tian Lian | Zendy; Shiyuan Huang | Zendy; Yong Yang | Zendy; Longxian Cheng | Zendy; Kun Liu | Zendy

Open Access

GABA and Topiramate Inhibit the Formation of Human Macrophage-Derived Foam Cells by Modulating Cholesterol-Metabolism-Associated Molecules

Author(s) -

Yongqiang Yang,

Yi-tian Lian,

Shiyuan Huang,

Yong Yang,

Longxian Cheng,

Kun Liu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358681

Subject(s) - gabaergic , lipid metabolism , chemistry , macrophage , microbiology and biotechnology , foam cell , topiramate , pharmacology , receptor , biology , endocrinology , biochemistry , neuroscience , in vitro , epilepsy

γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, acts on GABA receptors to play an important role in the modulation of macrophage functions. The present study examined the effects of GABA and a GABA receptor agonist on modulating cholesterol-metabolism-associated molecules in human monocyte-derived macrophages (HMDMs).

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