Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets | Zendy

Rosiane Aparecida Miranda | Zendy; Aryane Rodrigues Agostinho | Zendy; Isis Hara Trevenzoli | Zendy; Luiz F. Barella | Zendy; Claudinéia C. S. Franco | Zendy; Amanda Bianchi Trombini | Zendy; Ananda Malta | Zendy; Clarice Gravena | Zendy; Rosana Torrezan | Zendy; Paulo Cézar de Freitas Mathias | Zendy; Júlio Cézar de Oliveira | Zendy

Open Access

Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets

Author(s) -

Rosiane Aparecida Miranda,

Aryane Rodrigues Agostinho,

Isis Hara Trevenzoli,

Luiz F. Barella,

Claudinéia C. S. Franco,

Amanda Bianchi Trombini,

Ananda Malta,

Clarice Gravena,

Rosana Torrezan,

Paulo Cézar de Freitas Mathias,

Júlio Cézar de Oliveira

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358677

Subject(s) - medicine , endocrinology , monosodium glutamate , muscarinic acetylcholine receptor , pancreatic islets , insulin , muscarinic acetylcholine receptor m3 , muscarinic antagonist , diabetes mellitus , antagonist , islet , receptor

Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens. We aimed to characterize the muscarinic acetylcholine receptor (mAChR) M1-M4 subtypes in isolated pancreatic islets from pre-diabetic obese rats that had been treated neonatally with monosodium L-glutamate (MSG).

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