In VivoDesflurane Preconditioning Evokes Dynamic Alterations of Metabolic Proteins in the Heart - Proteomic Insights Strengthen the Link between Bioenergetics and Cardioprotection
Author(s) -
Nadine DyballaRukes,
Christian Schuh,
Hendrik Vogt,
Octavian Toma,
W. Schlack,
Nina C. Weber,
Sabine Metzger
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000358668
Subject(s) - cardioprotection , proteome , ischemic preconditioning , bioenergetics , proteomics , chemistry , nad+ kinase , homeostasis , biology , microbiology and biotechnology , biochemistry , ischemia , mitochondrion , medicine , enzyme , gene
The cardioprotective effect of anaesthetic preconditioning as measured by reduction of ischaemia-reperfusion (I/R) injury is a well described phenomenon. However little is known about the impact on the myocardial proteome. We therefore investigated proteome dynamics at different experimental time points of a preconditioning protocol.
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