�-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes | Zendy

Xiaoxia Shi | Zendy; Xinwei Li | Zendy; Dangdang Li | Zendy; Yu Li | Zendy; Yuxiang Song | Zendy; Qinghua Deng | Zendy; Jianguo Wang | Zendy; Yuhang Zhang | Zendy; Hongyan Ding | Zendy; Liheng Yin | Zendy; Yuming Zhang | Zendy; Zhe Wang | Zendy; Xiaobing Li | Zendy; Guowen Liu | Zendy

Open Access

�-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes

Author(s) -

Xiaoxia Shi,

Xinwei Li,

Dangdang Li,

Yu Li,

Yuxiang Song,

Qinghua Deng,

Jianguo Wang,

Yuhang Zhang,

Hongyan Ding,

Liheng Yin,

Yuming Zhang,

Zhe Wang,

Xiaobing Li,

Guowen Liu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358664

Subject(s) - pyrrolidine dithiocarbamate , oxidative stress , inflammation , chemistry , nf κb , pharmacology , iκbα , antioxidant , endocrinology , medicine , biochemistry , biology

β-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA is related to the inflammation involved in other diseases of dairy cattle. However, whether BHBA can induce inflammatory injury in dairy cow hepatocytes and the potential mechanism of this induction are not clear. The NF-κB pathway plays a vital role in the inflammatory response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research