Neurogenin 2 Converts Mesenchymal Stem Cells into a Neural Precursor Fate and Improves Functional Recovery after Experimental Stroke | Zendy

Feng Cheng | Zendy; Xiaocheng Lu | Zendy; Huai Yong Hao | Zendy; Xue Liang Dai | Zendy; Teng Da Qian | Zendy; Bao Sheng Huang | Zendy; Lin Tang | Zendy; Wan Yu | Zendy; Li Xin Li | Zendy

Open Access

Neurogenin 2 Converts Mesenchymal Stem Cells into a Neural Precursor Fate and Improves Functional Recovery after Experimental Stroke

Author(s) -

Feng Cheng,

Xiaocheng Lu,

Huai Yong Hao,

Xue Liang Dai,

Teng Da Qian,

Bao Sheng Huang,

Lin Tang,

Wan Yu,

Li Xin Li

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358657

Subject(s) - mesenchymal stem cell , neun , transplantation , neural stem cell , neurosphere , nestin , biology , microbiology and biotechnology , stem cell , pathology , immunology , medicine , adult stem cell , immunohistochemistry , endothelial stem cell , in vitro , biochemistry

Neurogenin2 (Ngn2) is a proneural gene that directs neuronal differentiation of progenitor cells during development. Here, we investigated whether Ngn2 can reprogram MSCs to adopt a neural precursor fate and enhance the therapeutic effects of MSCs after experimental stroke.

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