GM-CSF Induces Cyclin D1 Expression and Proliferation of Endothelial Progenitor Cells via PI3K and MAPK Signaling | Zendy

Chaolin Qiu | Zendy; Qiuhua Xie | Zendy; Dongqing Zhang | Zendy; Qing Chen | Zendy; Jinhui Hu | Zendy; Limin Xu | Zendy

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GM-CSF Induces Cyclin D1 Expression and Proliferation of Endothelial Progenitor Cells via PI3K and MAPK Signaling

Author(s) -

Chaolin Qiu,

Qiuhua Xie,

Dongqing Zhang,

Qing Chen,

Jinhui Hu,

Limin Xu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358652

Subject(s) - cyclin d1 , progenitor cell , mapk/erk pathway , microbiology and biotechnology , protein kinase b , cancer research , cell cycle , angiogenesis , pi3k/akt/mtor pathway , biology , cyclin , cyclin d , endothelial progenitor cell , retinoblastoma protein , cyclin d3 , signal transduction , stem cell , cell , biochemistry

Endothelial progenitor cells (EPCs), which can be isolated from the bone marrow or the peripheral blood, have generated interest because of their capacity to migrate to sites of vascularization and endothelialization and differentiate into endothelial cells in a process termed neovasculogenesis. EPCs are therefore possible regenerative tools for the treatment of vascular diseases and potential targets for the inhibition of angiogenesis during tumor development. Here, we investigated the mechanisms underlying the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the acceleration of EPC proliferation and colony formation.

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