Role of Mitofusin-2 in High Mobility Group Box-1 Protein-Mediated Apoptosis of T Cellsin Vitro | Zendy

Zongsheng Wu | Zendy; Yong-ming Yao | Zendy; Guangliang Hong | Zendy; Xiuping Xu | Zendy; Yao Liu | Zendy; Ning Dong | Zendy; JiaYi Zheng | Zendy; Zhongqiu Lu | Zendy; Guangju Zhao | Zendy; Xiaomei Zhu | Zendy; Qinghong Zhang | Zendy; Zhi-yong Sheng | Zendy

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Role of Mitofusin-2 in High Mobility Group Box-1 Protein-Mediated Apoptosis of T Cellsin Vitro

Author(s) -

Zongsheng Wu,

Yong-ming Yao,

Guangliang Hong,

Xiuping Xu,

Yao Liu,

Ning Dong,

JiaYi Zheng,

Zhongqiu Lu,

Guangju Zhao,

Xiaomei Zhu,

Qinghong Zhang,

Zhi-yong Sheng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358651

Subject(s) - mfn2 , apoptosis , jurkat cells , annexin , microbiology and biotechnology , biology , transfection , flow cytometry , dna fragmentation , hmgb1 , programmed cell death , mitochondrial fusion , t cell , cell culture , immune system , immunology , inflammation , mitochondrial dna , biochemistry , genetics , gene

High mobility group box-1 protein (HMGB1), a ubiquitous nuclear protein, which is recognized as a danger-associated molecular pattern (DAMP) triggering activation of the innate immune system. Previous studies have shown that HMGB1 also plays a role in T cell-mediated immunity, but the effect of HMGB1 on apoptosis of T cells and its precise mechanism remain to be determined.

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