Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model | Zendy

Li Liu | Zendy; Ting Hong Ye | Zendy; Yuan Han | Zendy; Hang Song | Zendy; Yong Kui Zhang | Zendy; Yong Xia | Zendy; Ningyu Wang | Zendy; Ying Xiong | Zendy; Xue Jiao Song | Zendy; Yong Xia Zhu | Zendy; De Liang Li | Zendy; Jun Zeng | Zendy; Kai Ran | Zendy; Cui Ting Peng | Zendy; Yu Wei | Zendy; Luo Ting Yu | Zendy

Open Access

Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model

Author(s) -

Li Liu,

Ting Hong Ye,

Yuan Han,

Hang Song,

Yong Kui Zhang,

Yong Xia,

Ningyu Wang,

Ying Xiong,

Xue Jiao Song,

Yong Xia Zhu,

De Liang Li,

Jun Zeng,

Kai Ran,

Cui Ting Peng,

Yu Wei,

Luo Ting Yu

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358640

Subject(s) - cancer research , medicine , tumor microenvironment , tumor progression , apoptosis , metastasis , lung cancer , cancer , pathology , biology , tumor cells , biochemistry

AZD4547, a small-molecule inhibitor targeting the tyrosine kinase of Fibroblast Growth Factor Receptors (FGFRs), is currently under phase II clinical study for human subjects having breast cancer, while the underlying mechanism remains elusive. The aim of this study is to explore the potential mechanism by which AZD4547 inhibits breast tumor lung metastases at the level of the tumor microenvironment.

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