Impairment of Circulating CD4+CD25+GARP+Regulatory T Cells in Patients with Acute Coronary Syndrome | Zendy

Kai Meng | Zendy; Wei Zhang | Zendy; Yucheng Zhong | Zendy; Xiaobo Mao | Zendy; Yingzhong Lin | Zendy; Ying Huang | Zendy; Mingjian Lang | Zendy; Yudong Peng | Zendy; Zhengfeng Zhu | Zendy; Yuzhou Liu | Zendy; Xiaoqi Zhao | Zendy; Kunwu Yu | Zendy; Bangwei Wu | Zendy; Qingwei Ji | Zendy; Qiutang Zeng | Zendy

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Impairment of Circulating CD4⁺CD25⁺GARP⁺Regulatory T Cells in Patients with Acute Coronary Syndrome

Author(s) -

Kai Meng,

Wei Zhang,

Yucheng Zhong,

Xiaobo Mao,

Yingzhong Lin,

Ying Huang,

Mingjian Lang,

Yudong Peng,

Zhengfeng Zhu,

Yuzhou Liu,

Xiaoqi Zhao,

Kunwu Yu,

Bangwei Wu,

Qingwei Ji,

Qiutang Zeng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358639

Subject(s) - foxp3 , il 2 receptor , immunology , pathogenesis , medicine , immune system , peripheral blood mononuclear cell , t cell , biology , in vitro , biochemistry

Atherosclerosis (AS) is an inflammatory and immune disease. Regulatory T cells (Tregs) suppress the activation of T cells and have been shown to play a protective role during the pathogenesis of AS. However, specific markers for Tregs are lacking. Recently, glycoprotein A repetitions predominant (GARP) was discovered as a specific marker of activated Tregs, and we therefore utilized GARP as a specific surface marker for Tregs in the current study.

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