PPARγ-Induced Stimulation of Amiloride-Sensitive Sodium Current in Renal Collecting Duct Principal Cells is Serum and Insulin Dependent | Zendy

Ahmed Chraïbi | Zendy; Stéphane Renauld | Zendy

Open Access

PPARγ-Induced Stimulation of Amiloride-Sensitive Sodium Current in Renal Collecting Duct Principal Cells is Serum and Insulin Dependent

Author(s) -

Ahmed Chraïbi,

Stéphane Renauld

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358636

Subject(s) - epithelial sodium channel , sgk1 , rosiglitazone , endocrinology , medicine , amiloride , renal sodium reabsorption , pioglitazone , aldosterone , chemistry , insulin , reabsorption , type 2 diabetes , kidney , sodium , diabetes mellitus , glucocorticoid , organic chemistry

Thiazolidinediones (TZDs), such as rosiglitazone or pioglitazone, are peroxisome proliferator-activated receptor gamma (PPARγ) agonists currently used in the treatment of type 2 diabetes. However, their clinical applicability is limited by common and severe side effects including strong water retention, edema and cardiac stroke. The precise mechanisms leading to these disorders are not clearly understood and remain controversial. While the nature of the disorders due to TZDs points to an increase in ENaC-mediated sodium reabsorption in the aldosterone-sensitive distal nephron, some studies suggested that this channel was not targeted by PPARγ agonists.

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