Calcium Sensing Receptor Promotes Cardiac Fibroblast Proliferation and Extracellular Matrix Secretion | Zendy

Xinying Zhang | Zendy; Tiemin Zhang | Zendy; Jichao Wu | Zendy; Xiangjing Yu | Zendy; Dan Zheng | Zendy; Fan Yang | Zendy; Ting Li | Zendy; Lina Wang | Zendy; Yajun Zhao | Zendy; Shiyun Dong | Zendy; Xin Zhong | Zendy; Songbin Fu | Zendy; Changqing Xu | Zendy; Fanghao Lu | Zendy; Weihua Zhang | Zendy

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Calcium Sensing Receptor Promotes Cardiac Fibroblast Proliferation and Extracellular Matrix Secretion

Author(s) -

Xinying Zhang,

Tiemin Zhang,

Jichao Wu,

Xiangjing Yu,

Dan Zheng,

Fan Yang,

Ting Li,

Lina Wang,

Yajun Zhao,

Shiyun Dong,

Xin Zhong,

Songbin Fu,

Changqing Xu,

Fanghao Lu,

Weihua Zhang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358634

Subject(s) - cardiac fibrosis , fibroblast , extracellular matrix , calcium in biology , extracellular , microbiology and biotechnology , intracellular , endocrinology , calcium , biology , medicine , chemistry , fibrosis , cell culture , genetics

Calcium-sensing receptor (CaR) acts as a G protein coupled receptor that mediates the increase of the intracellular Ca(2+) concentration. The expression of CaR has been confirmed in various cell types, including cardiomyocytes, smooth muscle cells, neurons and vascular endothelial cells. However, whether CaR is expressed and functions in cardiac fibroblasts has remained unknown. The present study investigated whether CaR played a role in cardiac fibroblast proliferation and extracellular matrix (ECM) secretion, both in cultured rat neonatal cardiac fibroblasts and in a model of cardiac hypertrophy induced by isoproterenol (ISO).

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