A Newly Cloned ClC-3 Isoform, ClC-3d, as well as ClC-3a Mediates Cd2+-Sensitive Outwardly Rectifying Anion Currents | Zendy

Toshiaki Okada | Zendy; Tenpei Akita | Zendy; Kaori Sato | Zendy; Md. Rafqul Islam | Zendy; Yasunobu Okada | Zendy

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A Newly Cloned ClC-3 Isoform, ClC-3d, as well as ClC-3a Mediates Cd²⁺-Sensitive Outwardly Rectifying Anion Currents

Author(s) -

Toshiaki Okada,

Tenpei Akita,

Kaori Sato,

Md. Rafqul Islam,

Yasunobu Okada

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358633

Subject(s) - gene isoform , hek 293 cells , transfection , peptide sequence , amino acid , cloning (programming) , chemistry , microbiology and biotechnology , biochemistry , biology , gene , computer science , programming language

ClC-3, a member of the ClC family, is predicted to have six isoforms, ClC-3a to -3f, with distinct N- and C-terminal amino acid sequences. There have been conflicting reports on the properties of ClC-3a (also known as the N-terminal short form of ClC-3) and ClC-3b (the N-terminal long form of ClC-3) as plasmalemmal Cl(-) channels. Meanwhile, little is known about other isoforms. The amino acid sequence of ClC-3d (a C-terminal variant of the short form) listed in the NCBI database was derived from the genomic sequence, but there has been no experimental evidence for the mRNA.

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