Activation of a7 Nicotinic Acetylcholine Receptor Protects Against Oxidant Stress Damage Through Reducing Vascular Peroxidase-1 in a JNK Signaling-Dependent Manner in Endothelial Cells | Zendy

Dongjie Li | Zendy; Ting Zhao | Zendy; Rujuan Xin | Zendy; YuanYuan Wang | Zendy; Yi-Bo Fei | Zendy; FuMing Shen | Zendy

Open Access

Activation of a7 Nicotinic Acetylcholine Receptor Protects Against Oxidant Stress Damage Through Reducing Vascular Peroxidase-1 in a JNK Signaling-Dependent Manner in Endothelial Cells

Author(s) -

Dongjie Li,

Ting Zhao,

Rujuan Xin,

YuanYuan Wang,

Yi-Bo Fei,

FuMing Shen

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358627

Subject(s) - methyllycaconitine , microbiology and biotechnology , viability assay , chemistry , downregulation and upregulation , oxidative stress , signal transduction , apoptosis , pharmacology , biology , receptor , nicotinic agonist , nicotinic acetylcholine receptor , biochemistry , gene

Alpha7 nicotinic acetylcholine receptor (α7nAChR), a subtype of nAChR regulating neurotransmission in central nervous system, is an essential regulator of cholinergic anti-inflammatory pathway in periphery. The present study was to determine the effects of activation of α7nAChR on oxidant stress-induced injury in endothelial cells.

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