miR-4782-3p Inhibited Non-Small Cell Lung Cancer growth via USP14 | Zendy

Ning Wu | Zendy; Chaoxiong Zhang | Zendy; Chong Bai | Zendy; Yi Han | Zendy; Qiang Li | Zendy

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miR-4782-3p Inhibited Non-Small Cell Lung Cancer growth via USP14

Author(s) -

Ning Wu,

Chaoxiong Zhang,

Chong Bai,

Yi Han,

Qiang Li

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358626

Subject(s) - microrna , lung cancer , deubiquitinating enzyme , biology , cancer research , cancer , cell growth , gene , microbiology and biotechnology , oncology , ubiquitin , medicine , genetics

Lung cancer is the leading cause of cancer-related mortality worldwide, with near 1.4 million deaths each year. NSCLC accounts for nearly 85% of all case of lung cancer. MiRNAs play important roles in regulation of gene expression at the post-transcriptional level. MiRNAs profiles may predict prognosis and disease recurrence in early-stage NSCLC. Our previous study proved that over-expression of ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, was associated with favorable prognosis in NSCLC patients and promoted tumor cells proliferation. Here, we tried to identify which miRNAs targeted USP14, and the roles of these miRNAs in NSCLC.

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