Exendin-4 Alleviates High Glucose-Induced Rat Mesangial Cell Dysfunction through the AMPK Pathway | Zendy

Wen-Wei Xu | Zendy; Meiping Guan | Zendy; Zongji Zheng | Zendy; Fang Gao | Zendy; Yanmei Zeng | Zendy; Yan Qin | Zendy; Yaoming Xue | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Exendin-4 Alleviates High Glucose-Induced Rat Mesangial Cell Dysfunction through the AMPK Pathway

Author(s) -

Wen-Wei Xu,

Meiping Guan,

Zongji Zheng,

Fang Gao,

Yanmei Zeng,

Yan Qin,

Yaoming Xue

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000358623

Subject(s) - ampk , fibronectin , endocrinology , protein kinase a , chemistry , medicine , phosphorylation , pi3k/akt/mtor pathway , mesangial cell , signal transduction , mapk/erk pathway , cell growth , kinase , microbiology and biotechnology , biology , cell , kidney , biochemistry

Glucagon-like peptide-1 (GLP-1), which counteracts insulin resistance in humans with type 2 diabetes, has been shown to ameliorate diabetic nephropathy in experimental models. However, the mechanisms through which GLP-1 modulates renal function remained illdefined. The present study investigated the putative mechanisms underlying effects of exendin-4, a GLP-1 analog, on mesangial cell proliferation and fibronectin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research