Stem Cells, Retinal Ganglion Cells and Glaucoma | Zendy

Valentin M. Sluch | Zendy; Donald J. Zack | Zendy

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Stem Cells, Retinal Ganglion Cells and Glaucoma

Author(s) -

Valentin M. Sluch,

Donald J. Zack

Publication year - 2014

Publication title -

developments in ophthalmology

Language(s) - English

Resource type - Book series

SCImago Journal Rank - 1.112

H-Index - 34

eISSN - 1662-2790

pISSN - 0250-3751

DOI - 10.1159/000358409

Subject(s) - stem cell , neuroscience , retinal , optic nerve , retina , intrinsically photosensitive retinal ganglion cells , retinal ganglion cell , glaucoma , biology , cell type , microbiology and biotechnology , cell , medicine , ophthalmology , genetics

Retinal ganglion cells (RGCs) represent an essential neuronal cell type for vision. These cells receive inputs from light-sensing photoreceptors via retinal interneurons and then relay these signals to the brain for further processing. RGC diseases that result in cell death, e.g. glaucoma, often lead to permanent damage since mammalian nerves do not regenerate. Stem cell differentiation can generate cells needed for replacement or can be used to generate cells capable of secreting protective factors to promote survival. In addition, stem cell-derived cells can be used in drug screening research. Here, we discuss the current state of stem cell research potential for interference in glaucoma and other optic nerve diseases with a focus on stem cell differentiation to RGCs.

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