Storage-Induced Damage to Red Blood Cell Mechanical Properties Can Be Only Partially Reversed by Rejuvenation | Zendy

Gregory Barshtein | Zendy; Alexander Gural | Zendy; Noga Manny | Zendy; Orly Zelig | Zendy; Saul Yedgar | Zendy; Dan Arbell | Zendy

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Storage-Induced Damage to Red Blood Cell Mechanical Properties Can Be Only Partially Reversed by Rejuvenation

Author(s) -

Gregory Barshtein,

Alexander Gural,

Noga Manny,

Orly Zelig,

Saul Yedgar,

Dan Arbell

Publication year - 2014

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000357986

Subject(s) - erythrocyte fragility , red blood cell , chemistry , andrology , hemolysis , microbiology and biotechnology , biochemistry , biology , immunology , medicine

The storage of red blood cells (RBC) is associated with impairment of their properties that can induce a circulatory risk to recipients. In a preceding study (2009), we reported that post-storage rejuvenation (RJ) of stored RBC (St-RBC) efficiently reduced the storage-induced RBC/endothelial cell interaction, while only partially reversing the level of intracellular Ca(2+), reactive oxygen species, and surface phosphatidylserine. In the present study, we examined the RJ effectiveness in repairing St-RBC mechanical properties.

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