Development, Manufacturing and Characterization of a Highly Purified, Liquid Immunoglobulin G Preparation from Human Plasma | Zendy

Inga Laursen | Zendy; Lene Blou | Zendy; John S. Sullivan | Zendy; Peter Fibiger Bang | Zendy; Flemming Balstrup | Zendy; Gunnar Houen | Zendy

Open Access

Development, Manufacturing and Characterization of a Highly Purified, Liquid Immunoglobulin G Preparation from Human Plasma

Author(s) -

Inga Laursen,

Lene Blou,

John S. Sullivan,

Peter Fibiger Bang,

Flemming Balstrup,

Gunnar Houen

Publication year - 2014

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000357982

Subject(s) - antibody , human plasma , immunoglobulin g , characterization (materials science) , chromatography , chemistry , immunology , medicine , materials science , nanotechnology

The use of plasma-derived immunoglobulin G (IgG) is increasing, and the number of diseases, including immunodeficiencies, neurological diseases and autoimmune conditions, treated with intravenous IgG (IVIG) is expanding. Consequently, there is a great need for high-yield production processes for plasma-derived IgG. The aim of this work was to develop a high-yield process leading to a highly purified, liquid, ready-to-use IgG for intravenous use.

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