Gene Expression Changes in Spleens and Livers of Tumour-Bearing Mice Suggest Delayed Inflammation and Attenuated Cachexia in Response to Oil Palm Phenolics | Zendy

Soon-Sen Leow | Zendy; Shamala Devi Sekaran | Zendy; Kalyana Sundram | Zendy; YewAi Tan | Zendy; Ravigadevi Sambanthamurthi | Zendy

Open Access

Gene Expression Changes in Spleens and Livers of Tumour-Bearing Mice Suggest Delayed Inflammation and Attenuated Cachexia in Response to Oil Palm Phenolics

Author(s) -

Soon-Sen Leow,

Shamala Devi Sekaran,

Kalyana Sundram,

YewAi Tan,

Ravigadevi Sambanthamurthi

Publication year - 2013

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 30

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000357948

Subject(s) - cachexia , palm oil , inflammation , gene , gene expression , inflammatory response , biology , bearing (navigation) , cancer research , immunology , cancer , genetics , food science , cartography , geography

Plant phenolics can inhibit, retard or reverse carcinogenesis, and may thus help prevent or treat cancer. Oil palm phenolics (OPP) previously showed anti-tumour activities in vivo via a cytostatic mechanism at 1,500 ppm gallic acid equivalent. Here, we report other possible molecular mechanisms by which this extract attenuates cancer, especially those concerning the immune response.

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