Autoantibodies to Oxidized Low-Density Lipoprotein in Patients with Aortic Regurgitation: Association with Aortic Diameter Size | Zendy

Sara Shimoni | Zendy; Iris Bar | Zendy; Liaz Zilberman | Zendy; Jacob George | Zendy

Open Access

Autoantibodies to Oxidized Low-Density Lipoprotein in Patients with Aortic Regurgitation: Association with Aortic Diameter Size

Author(s) -

Sara Shimoni,

Iris Bar,

Liaz Zilberman,

Jacob George

Publication year - 2014

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000357835

Subject(s) - medicine , cardiology , ventricle , oxidative stress , regurgitation (circulation) , aorta , autoantibody , lipoprotein , ascending aorta , endocrinology , antibody , cholesterol , immunology

Aortic regurgitation (AR) is a condition associated with volume overload, causing left-ventricular (LV) remodeling, eccentric LV hypertrophy and eventually heart failure. LV remodeling associated with AR is regulated by mechanical stress, neurohormonal activation, inflammation and oxidative stress. Since anti-oxidized low-density lipoprotein (LDL) antibodies (Abs) are a measurable marker of oxidative stress, we hypothesized that an increased level of circulating oxidized LDL (oxLDL) Abs may be related to remodeling of the left ventricle in patients with significant AR.

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