Open AccessAnalysis of <b><i>KRAS</i></b> Mutations in Cases of Metastatic Colorectal Cancer at a Single Institution in Tochigi, Japan
Author(s) -
Natsuko Saito,
Shigeki Tomita,
Kazuhito Ichikawa,
Hiroyuki Mitomi,
Johji Imura,
Takahiro Fujimori
Publication year - 2014
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000357812
Subject(s) - kras , colorectal cancer , medicine , cancer , cancer research
Colorectal cancer patients bearing wild-type KRAS benefit from anti-epidermal growth factor receptor (EGFR) antibody treatment. Since clinical studies showed the efficacy of anti-EGFR antibody treatment for metastatic colorectal cancer (mCRC), we analyzed KRAS mutations in mCRC to gain insight into the association between these mutations and clinicopathological characteristics.
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