Open AccessManagement of Hypotension in Preterm Infants (The HIP Trial): A Randomised Controlled Trial of Hypotension Management in Extremely Low Gestational Age Newborns
Author(s) -
Eugene Dempsey,
Keith J. Barrington,
Neil Marlow,
Colm P. O’Donnell,
Jan Miletín,
Gunnar Naulaers,
PoYin Cheung,
David Corcoran,
Gérard Pons,
Zbyněk Straňák,
David Van Laere
Publication year - 2014
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000357553
Subject(s) - medicine , gestation , gestational age , randomized controlled trial , pediatrics , anesthesia , blood pressure , pregnancy , genetics , biology
Extremely preterm babies (delivered at <28 completed weeks of gestation) are frequently diagnosed with hypotension and treated with inotropic and pressor drugs in the immediate postnatal period. Dopamine is the most commonly used first-line drug. Babies who are treated for hypotension more frequently sustain brain injury, have long-term disability or die compared to those who are not. Despite the widespread use of drugs to treat hypotension in such infants, evidence for efficacy is lacking, and the effect of these agents on long-term outcomes is unknown.
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