Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Inducing SOCS1 Expression | Zendy

Xiaodong Xu | Zendy; Junwen Zheng | Zendy; Kun Zheng | Zendy; Hou Yan | Zendy; Feng Zhao | Zendy; Dongchi Zhao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Inducing SOCS1 Expression

Author(s) -

Xiaodong Xu,

Junwen Zheng,

Kun Zheng,

Hou Yan,

Feng Zhao,

Dongchi Zhao

Publication year - 2014

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000357327

Subject(s) - suppressor of cytokine signaling 1 , stat2 , socs3 , tlr3 , biology , microbiology and biotechnology , interferon , signal transduction , phosphorylation , stat , virology , stat3 , gene , innate immune system , immunology , immune system , biochemistry , suppressor , toll like receptor

Respiratory syncytial virus (RSV) nonstructural protein NS1 (NS1) has been shown to block interferon (IFN)-inducible antiviral signaling. The suppressor of cytokine signaling (SOCS) gene family could utilize a feedback loop to block the activation of the JAK/STAT signaling pathway, further inhibiting the activation of host type I IFN. We evaluated the role of the SOCS1 and SOCS3 genes in this antiviral mechanism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research