How Good Is the Neosquamous Epithelium? | Zendy

Roy C. Orlando | Zendy

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How Good Is the Neosquamous Epithelium?

Author(s) -

Roy C. Orlando

Publication year - 2014

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000357185

Subject(s) - tight junction , barrier function , downregulation and upregulation , epithelium , claudin , paracellular transport , medicine , pathology , microbiology and biotechnology , permeability (electromagnetism) , chemistry , biology , biochemistry , membrane , gene

Endoscopic radiofrequency ablation of dysplastic Barrett's esophagus (BE) combined with proton pump inhibitor therapy is commonly utilized for preventing progression of dysplastic BE to esophageal adenocarcinoma. Fundamental to the success of this and all ablative approaches is the healing of the ablated areas of BE with a stratified squamous epithelium referred to as 'neosquamous epithelium' (NSE). Although NSE appears 'normal' endoscopically, the reemergence of BE over time in the previously ablated segments raises the question of the health and integrity of NSE.

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