Dengue Virus Serotype-2 Impairs Proliferation of Healthy Donors' T Lymphocytes | Zendy

C.J. Fuentes-Miranda | Zendy; F. J. SánchezGarcía | Zendy; Amin Coker | Zendy; O Rojas-Espinosa | Zendy; R. Salinas-Tobón | Zendy; María Maximina Bertha MorenoAltamirano | Zendy

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Dengue Virus Serotype-2 Impairs Proliferation of Healthy Donors' T Lymphocytes

Author(s) -

C.J. Fuentes-Miranda,

F. J. SánchezGarcía,

Amin Coker,

O Rojas-Espinosa,

R. Salinas-Tobón,

María Maximina Bertha MorenoAltamirano

Publication year - 2014

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000357180

Subject(s) - dengue virus , biology , t cell , cd8 , il 2 receptor , virology , immune system , immunology , t lymphocyte , dengue fever

T lymphocytes are not infected by dengue virus (DENV), nevertheless it is possible that exposure to DENV may affect their function. T lymphocytes from DENV-infected individuals are impaired in their proliferative capacity, although this effect has been attributed to altered function of antigen-presenting cells rather than to an intrinsic defect on T lymphocytes. Here we analyzed whether T lymphocytes from healthy donors became impaired in their proliferative capacity following in vitro exposure to DENV serotype-2 (DENV-2), as well as the possible mechanisms for this.

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