High Lactate Dehydrogenase 5 Expression Correlates with High Tumoral and Stromal Vascular Endothelial Growth Factor Expression in Gastric Cancer | Zendy

Hee Sung Kim | Zendy; Hee Eun Lee | Zendy; HanKwang Yang | Zendy; WonHo Kim | Zendy

Open Access

High Lactate Dehydrogenase 5 Expression Correlates with High Tumoral and Stromal Vascular Endothelial Growth Factor Expression in Gastric Cancer

Author(s) -

Hee Sung Kim,

Hee Eun Lee,

HanKwang Yang,

WonHo Kim

Publication year - 2013

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000357017

Subject(s) - stromal cell , lactate dehydrogenase , vascular endothelial growth factor , cancer , immunohistochemistry , medicine , metastasis , pathology , cancer research , biology , vegf receptors , enzyme , biochemistry

Lactate dehydrogenase 5 (LDH5) is a major lactate dehydrogenase isoenzyme catalyzing the transformation of pyruvate to lactate to provide anaerobic energy. Vascular endothelial growth factor (VEGF) is expressed in both tumor and stromal cells in gastric cancer. Our aim was to study the prognostic effect of LDH5, and tumoral and stromal expression of the angiogenic factor VEGF in gastric cancer, and the intercorrelation of tissue expression of both factors.

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