Blood Markers of Coagulation, Fibrinolysis, Endothelial Dysfunction and Inflammation in Lacunar Stroke versus Non-Lacunar Stroke and Non-Stroke: Systematic Review and Meta-Analysis | Zendy

Stewart Wiseman | Zendy; Fergal Marlborough | Zendy; Fergus Doubal | Zendy; David J. Webb | Zendy; Joanna M. Wardlaw | Zendy

Open Access

Blood Markers of Coagulation, Fibrinolysis, Endothelial Dysfunction and Inflammation in Lacunar Stroke versus Non-Lacunar Stroke and Non-Stroke: Systematic Review and Meta-Analysis

Author(s) -

Stewart Wiseman,

Fergal Marlborough,

Fergus Doubal,

David J. Webb,

Joanna M. Wardlaw

Publication year - 2013

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000356789

Subject(s) - lacunar stroke , medicine , stroke (engine) , fibrinogen , fibrinolysis , tissue plasminogen activator , leukoaraiosis , cardiology , endothelial dysfunction , inflammation , ischemic stroke , ischemia , disease , dementia , mechanical engineering , engineering

The cause of cerebral small vessel disease is not fully understood, yet it is important, accounting for about 25% of all strokes. It also increases the risk of having another stroke and contributes to about 40% of dementias. Various processes have been implicated, including microatheroma, endothelial dysfunction and inflammation. A previous review investigated endothelial dysfunction in lacunar stroke versus mostly non-stroke controls while another looked at markers of inflammation and endothelial damage in ischaemic stroke in general. We have focused on blood markers between clinically evident lacunar stroke and other subtypes of ischaemic stroke, thereby controlling for stroke in general.

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