Open AccessMolecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review
Author(s) -
Nadège Minois
Publication year - 2014
Publication title -
gerontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.397
H-Index - 94
eISSN - 1423-0003
pISSN - 0304-324X
DOI - 10.1159/000356748
Subject(s) - spermidine , polyamine , putrescine , biology , autophagy , spermine , biochemistry , mechanism of action , microbiology and biotechnology , enzyme , in vitro , apoptosis
Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties. Its supplementation increases lifespan and resistance to stress, and decreases the occurrence of age-related pathology and loss of locomotor ability. Its mechanisms of action are just beginning to be understood.
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