Nicotine Elevated Intracellular Ca2+in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating a7-Nicotinic Acetylcholine Receptor | Zendy

YongLiang Jiang | Zendy; Aiguo Dai | Zendy; Yumin Zhou | Zendy; Gongyong Peng | Zendy; Guoping Hu | Zendy; Bing Li | Zendy; James S.K. Sham | Zendy; Pixin Ran | Zendy

Open Access

Nicotine Elevated Intracellular Ca²⁺in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating a7-Nicotinic Acetylcholine Receptor

Author(s) -

YongLiang Jiang,

Aiguo Dai,

Yumin Zhou,

Gongyong Peng,

Guoping Hu,

Bing Li,

James S.K. Sham,

Pixin Ran

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356678

Subject(s) - methyllycaconitine , nicotine , nicotinic acetylcholine receptor , nicotinic agonist , acetylcholine , intracellular , chemistry , medicine , endocrinology , acetylcholine receptor , microbiology and biotechnology , receptor , pharmacology , biology

Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia. Since tobacco use is the key risk factor for the development of COPD and intracellular Ca(2+) concentration ([Ca(2+)]i) plays a major role in both cell proliferation and differentiation, we hypothesized that nicotinic acetylcholine receptor (nAChR) activation plays a role in the elevation of [Ca(2+)]i in airway smooth muscle cells (ASMCs).

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