Modulation of BAG-1 Expression Alters the Sensitivity of Breast Cancer Cells to Tamoxifen | Zendy

Hong Liu | Zendy; Su Lu | Zendy; Lin Gu | Zendy; Yongchang Gao | Zendy; Tong Wang | Zendy; Jing Zhao | Zendy; Jianyu Rao | Zendy; Jun Chen | Zendy; Xishan Hao | Zendy; Shou-Ching Tang | Zendy

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Modulation of BAG-1 Expression Alters the Sensitivity of Breast Cancer Cells to Tamoxifen

Author(s) -

Hong Liu,

Su Lu,

Lin Gu,

Yongchang Gao,

Tong Wang,

Jing Zhao,

Jianyu Rao,

Jun Chen,

Xishan Hao,

Shou-Ching Tang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356676

Subject(s) - mcf 7 , tamoxifen , apoptosis , cancer cell , breast cancer , cell culture , cancer research , transfection , in vitro , cell , cancer , medicine , human breast , chemistry , pharmacology , biology , biochemistry , genetics

BAG-1 (bcl-2 associated athanogene) is a multifunctional protein that protects cells from a wide range of apoptotic stimuli including radiation, hypoxia and chemotherapeutic agents. Overexpression of cytoplasmic BAG-1 has been associated with the increased survival and decreased response to treatment with tamoxifen (TAM) in breast cancer. We attempted to assess the expression of BAG-1 in the human breast cancer cells that are resistant to treatment with 4-OH TAM and effect of altered BAG-1 expression on their sensitivity to 4-OH TAM.

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