Genipin Inhibits IL-1�-Induced CCL20 and IL-6 Production from Human Periodontal Ligament Cells | Zendy

Satoru Shindo | Zendy; Yoshitaka Hosokawa | Zendy; Ikuko Hosokawa | Zendy; Kazumi Ozaki | Zendy; Takashi Matsuo | Zendy

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Genipin Inhibits IL-1�-Induced CCL20 and IL-6 Production from Human Periodontal Ligament Cells

Author(s) -

Satoru Shindo,

Yoshitaka Hosokawa,

Ikuko Hosokawa,

Kazumi Ozaki,

Takashi Matsuo

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356675

Subject(s) - genipin , periodontal fiber , mapk/erk pathway , chemistry , pharmacology , microbiology and biotechnology , kinase , dentistry , medicine , biochemistry , biology , chitosan

Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of various diseases in traditional oriental medicine. Genipin has been used as a blue colorant in food industry. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify CCL20 and IL-6, which are related to bone resorption in periodontal disease, expression in human periodontal ligament cells (HPDLCs).

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