High Glucose Concentration Stimulates NHE-1 Activity in Distal Nephron Cells: the Role of the Mek/Erk1/2/p90RSKand p38MAPK Signaling Pathways | Zendy

Juliana da Costa Santos Pessoa | Zendy; Rosélia S. Damasceno | Zendy; Ubiratan Fabres Machado | Zendy; O. Beloto-Silva | Zendy; Maria OliveiraSouza | Zendy

Open Access

High Glucose Concentration Stimulates NHE-1 Activity in Distal Nephron Cells: the Role of the Mek/Erk1/2/p90^RSKand p38MAPK Signaling Pathways

Author(s) -

Juliana da Costa Santos Pessoa,

Rosélia S. Damasceno,

Ubiratan Fabres Machado,

O. Beloto-Silva,

Maria OliveiraSouza

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356673

Subject(s) - nephron , chemistry , sodium–hydrogen antiporter , l glucose , extracellular , cotransporter , sodium , intracellular ph , intracellular , medicine , microbiology and biotechnology , biochemistry , endocrinology , biology , diabetes mellitus , renal function , organic chemistry , islet

In models of diabetes, distal nephron cells contribute to glucose uptake and oxidation. How these cells contribute to the use of glucose for the regulation of H(+) extrusion remains unknown. We used Madin-Darby Canine Kidney (MDCK) cells to investigate the effect of acute or chronic high glucose concentration on the abundance and activity of the Na(+)/H(+) exchanger (NHE-1).

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