High Autophagy in the Naked Mole Rat may Play a Significant Role in Maintaining Good Health | Zendy

Shanmin Zhao | Zendy; Lifang Lin | Zendy; Guanghan Kan | Zendy; Chang Xu | Zendy; Qiu Tang | Zendy; ChenLin Yu | Zendy; Wei Sun | Zendy; Liping Cai | Zendy; Xu Chen | Zendy; Shufang Cui | Zendy

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High Autophagy in the Naked Mole Rat may Play a Significant Role in Maintaining Good Health

Author(s) -

Shanmin Zhao,

Lifang Lin,

Guanghan Kan,

Chang Xu,

Qiu Tang,

ChenLin Yu,

Wei Sun,

Liping Cai,

Xu Chen,

Shufang Cui

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356672

Subject(s) - autophagy , mole , apoptosis , hepatic stellate cell , flow cytometry , immunohistochemistry , blot , biology , basal (medicine) , messenger rna , medicine , endocrinology , microbiology and biotechnology , chemistry , andrology , immunology , biochemistry , gene , insulin

The maximum lifespan of the naked mole rat is over 28.3 years, which exceeds that of any other rodent species, suggesting that age-related changes in its body composition and functionality are either attenuated or delayed in this extraordinarily long-lived species. However, the mechanisms underlying the aging process in this species are poorly understood. In this study, we investigated whether long-lived naked mole rats display more autophagic activity than short-lived mice.

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