Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium | Zendy

Petra Waskova-Arnostova | Zendy; Dita Kašparová | Zendy; Barbara Elsnicová | Zendy; Jiřı́ Novotný | Zendy; Ján Neckář | Zendy; František Kolář | Zendy; Jitka Žurmanová | Zendy

Open Access

Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium

Author(s) -

Petra Waskova-Arnostova,

Dita Kašparová,

Barbara Elsnicová,

Jiřı́ Novotný,

Ján Neckář,

František Kolář,

Jitka Žurmanová

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356671

Subject(s) - creatine kinase , hexokinase , western blot , mitochondrion , hypoxia (environmental) , medicine , endocrinology , gene isoform , homeostasis , cytosol , biology , oxidative stress , apoptosis , enzyme , glycolysis , chemistry , biochemistry , metabolism , gene , oxygen , organic chemistry

Creatine kinase (CK) and hexokinase (HK) play a key role in myocardial energy homeostasis. We aimed to determine CK and HK expression and enzyme activity in the left (LV) and right (RV) ventricles of rats adapted for 3 weeks to normobaric hypoxia (10 % O2) either continuously (CNH) or intermittently with 1-h or 16-h normoxic episode per day.

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