DCP-LA-Phosphatidylinositol and Its Enantiomer Exhibit Different Bioactivities | Zendy

Ayako Tsuchiya | Zendy; Takeshi Kanno | Zendy; Tadashi Shimizu | Zendy; Syuhei Nakao | Zendy; Akito Tanaka | Zendy; Tomoyuki Nishizaki | Zendy

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DCP-LA-Phosphatidylinositol and Its Enantiomer Exhibit Different Bioactivities

Author(s) -

Ayako Tsuchiya,

Takeshi Kanno,

Tadashi Shimizu,

Syuhei Nakao,

Akito Tanaka,

Tomoyuki Nishizaki

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356670

Subject(s) - phosphatidylinositol , pi , phosphorylation , phosphatase , protein kinase c , enantiomer , inositol , chemistry , basal (medicine) , protein phosphatase 2 , microbiology and biotechnology , biochemistry , biology , stereochemistry , endocrinology , receptor , insulin

The present study was conducted to understand biochemical and biological characteristics of the phosphatidylinositol (PI) derivative 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-Sn-glycero-3-phosphatidyl-D-1-inositol (diDCP-LA-PI) and its enantiomer 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-Sn-glycero-3-phosphatidyl-L-1-inositol (diDCP-LA-PIe), with 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) on the α and β position.

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