Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells | Zendy

David R. Christensen | Zendy; Philip C. Calder | Zendy; Franchesca D. Houghton | Zendy

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Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells

Author(s) -

David R. Christensen,

Philip C. Calder,

Franchesca D. Houghton

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356665

Subject(s) - amino acid , embryonic stem cell , oxygen tension , oxygen , biochemistry , metabolism , biology , cell culture , microbiology and biotechnology , serine , limiting oxygen concentration , chemistry , genetics , organic chemistry , gene , enzyme

Human embryonic stem cells (hESCs) are a potential source of cells for treatment of many degenerative diseases, but in culture have a propensity to spontaneously differentiate, possibly due to suboptimal conditions. Culture at low oxygen tensions improves hESC maintenance and regulates carbohydrate metabolism. Hence, a greater understanding of the nutrient requirements of hESCs will allow production of more appropriate culture media. This study aims to investigate the effect of environmental oxygen tension on the amino acid metabolism of hESCs.

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