Atorvastatin Protects Vascular Smooth Muscle Cells From TGF-�1-Stimulated Calcification by Inducing Autophagy via Suppression of the �-Catenin Pathway | Zendy

Demin Liu | Zendy; Wei Cui | Zendy; Bin Liu | Zendy; Haijuan Hu | Zendy; Jing Liu | Zendy; Ruiqin Xie | Zendy; Xiaohong Yang | Zendy; Guoqiang Gu | Zendy; Jidong Zhang | Zendy; Hongmei Zheng | Zendy

Open Access

Atorvastatin Protects Vascular Smooth Muscle Cells From TGF-�1-Stimulated Calcification by Inducing Autophagy via Suppression of the �-Catenin Pathway

Author(s) -

Demin Liu,

Wei Cui,

Bin Liu,

Haijuan Hu,

Jing Liu,

Ruiqin Xie,

Xiaohong Yang,

Guoqiang Gu,

Jidong Zhang,

Hongmei Zheng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356656

Subject(s) - autophagy , atorvastatin , vascular smooth muscle , calcification , chemistry , microbiology and biotechnology , downregulation and upregulation , cancer research , apoptosis , medicine , endocrinology , biology , biochemistry , gene , smooth muscle

Arterial calcification is a major event in the progression of atherosclerosis. It is reported that statins exhibit various protective effects against vascular smooth muscle cell (VSMC) inflammation and proliferation in cardiovascular remodeling. Although statins counteract atherosclerosis, the molecular mechanisms of statins on the calcium release from VSMCs have not been clearly elucidated.

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