KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia | Zendy

Shanmin Zhao | Zendy; Yuxia Zhang | Zendy; Kun Sha | Zendy; Tang Qiu | Zendy; Xiaohua Yang | Zendy; ChenLin Yu | Zendy; Zhixue Liu | Zendy; Wei Sun | Zendy; Liping Cai | Zendy; Xu Chen | Zendy; Shufang Cui | Zendy

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KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia

Author(s) -

Shanmin Zhao,

Yuxia Zhang,

Kun Sha,

Tang Qiu,

Xiaohua Yang,

ChenLin Yu,

Zhixue Liu,

Wei Sun,

Liping Cai,

Xu Chen,

Shufang Cui

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356651

Subject(s) - kras , cancer research , myeloid leukemia , leukemia , bone marrow , myeloid , biology , immunophenotyping , cancer , neuroblastoma ras viral oncogene homolog , immunology , flow cytometry , colorectal cancer , genetics

It has been demonstrated that KRAS mutations represent about 90% of cancer-associated mutations, and that KRAS mutations play an essential role in neoplastic transformation. Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML), suggesting a functional role for Ras in leukemogenesis.

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