Heme Oxygenase-1 Mediates Oxidative Stress and Apoptosis in Coxsackievirus B3-Induced Myocarditis | Zendy

Oana Ursu | Zendy; Martina Sauter | Zendy; Nicole Ettischer | Zendy; Reinhard Kandolf | Zendy; Karin Klingel | Zendy

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Heme Oxygenase-1 Mediates Oxidative Stress and Apoptosis in Coxsackievirus B3-Induced Myocarditis

Author(s) -

Oana Ursu,

Martina Sauter,

Nicole Ettischer,

Reinhard Kandolf,

Karin Klingel

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356649

Subject(s) - downregulation and upregulation , oxidative stress , heme oxygenase , reactive oxygen species , viral myocarditis , myocarditis , apoptosis , microbiology and biotechnology , chemistry , heme , biology , biochemistry , medicine , gene , enzyme

Heme oxygenase-1 (HO-1), which is suggested to play a role in defending the organism against oxidative stress-mediated injuries, can be induced by diverse factors including viruses and iron. As coxsackievirus B3 (CVB3)-infected SWR/J mice susceptible for chronic myocarditis were found to have a significant iron incorporation and HO-1 upregulation in the myocardium, we aimed to investigate the molecular interplay between HO-1 expression and iron homeostasis in the outcome of viral myocarditis.

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