Melatonin Inhibits mTOR-Dependent Autophagy during Liver Ischemia/Reperfusion | Zendy

JungWoo Kang | Zendy; HongIk Cho | Zendy; SunMee Lee | Zendy

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Melatonin Inhibits mTOR-Dependent Autophagy during Liver Ischemia/Reperfusion

Author(s) -

JungWoo Kang,

HongIk Cho,

SunMee Lee

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356647

Subject(s) - autophagy , pi3k/akt/mtor pathway , calpain , melatonin , reperfusion injury , endogeny , ischemia , microbiology and biotechnology , chemistry , phosphorylation , reactive oxygen species , pharmacology , biology , apoptosis , signal transduction , medicine , endocrinology , biochemistry , enzyme

Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive oxygen species produced during ischemia/reperfusion (I/R). Melatonin (MLT) is a potent and endogenous anti-oxidant that has beneficial effects in liver I/R injury. In this study, we examined the cytoprotective mechanisms of MLT in liver I/R, focusing on autophagic flux and associated signaling pathways.

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