Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat | Zendy

Hui Che | Zendy; Lihua Sun | Zendy; Fei Guo | Zendy; Huifang Niu | Zendy; Xiaolin Su | Zendy; Yanan Bao | Zendy; Zidong Donna Fu | Zendy; Huailei Liu | Zendy; Xu Hou | Zendy; Baofeng Yang | Zendy; Jing Ai | Zendy

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Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat

Author(s) -

Hui Che,

Lihua Sun,

Fei Guo,

Huifang Niu,

Xiaolin Su,

Yanan Bao,

Zidong Donna Fu,

Huailei Liu,

Xu Hou,

Baofeng Yang,

Jing Ai

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356646

Subject(s) - forebrain , hippocampus , amyloid precursor protein , morris water navigation task , cortex (anatomy) , senile plaques , microrna , neuroscience , biology , alzheimer's disease , medicine , endocrinology , central nervous system , biochemistry , disease , gene

Aging is associated with the gradual cognitive decline and shows the typical senile plaque formation in the brain, which results from the aggregation of beta amyloid (Aβ) peptide following the abnormal proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase. Accumulating evidence indicates that several microRNAs (miRNAs) are involved in the Alzheimer's disease (AD) by regulating the expression of APP and BACE1 proteins. However, the cognitive ability and the expression profile of the APP- and BACE1-associated miRNAs in the middle-aged population are largely unknown.

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