CCK1-Receptor Stimulation Protects Against Gut Mediator-Induced Lung Damage During Endotoxemia | Zendy

Friederike Eisner | Zendy; Elizabeth M. Martin | Zendy; Markus A. Küper | Zendy; Helen E. Raybould | Zendy; Jörg Glatzle | Zendy

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CCK1-Receptor Stimulation Protects Against Gut Mediator-Induced Lung Damage During Endotoxemia

Author(s) -

Friederike Eisner,

Elizabeth M. Martin,

Markus A. Küper,

Helen E. Raybould,

Jörg Glatzle

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356644

Subject(s) - lymph , cholecystokinin , endocrinology , tunel assay , medicine , stimulation , lung , mesenteric lymph nodes , inflammation , myeloperoxidase , reflex , pharmacology , receptor , spleen , pathology , immunohistochemistry

Cholecystokinin 1-receptor (CCK1-R) activation by long chain fatty acid (LCFA) absorption stimulates vago-vagal reflex pathways in the brain stem. The present study determines whether this reflex also activates the cholinergic anti-inflammatory pathway, a pathway known to modulate cytokine release during endotoxemia.

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