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Monocyte chemoattractant protein-1 (MCP-1) plays an important role in extracellular matrix accumulation through macrophage recruitment and activation in the development and progression of diabetic nephropathy. Therefore, this study examined whether advanced oxidation protein products (AOPPs) are involved in nuclear factor-κB (NF-κB) activation and MCP-1 mRNA and protein expression in mesangial cells (MCs) and evaluated the effects of derivatives of sesquiterpene lactones (SLs) on AOPP-induced renal damage.

cellular physiology and biochemistry

AOPPs Induce MCP-1 Expression by Increasing ROS-Mediated Activation of the NF-&amp;#954;B Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones