AOPPs Induce MCP-1 Expression by Increasing ROS-Mediated Activation of the NF-&#954;B Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones | Zendy

Jiancheng Wang | Zendy; Yan Zhao | Zendy; SiJia Chen | Zendy; Jing Long | Zendy; Qianqian Jia | Zendy; Jiadai Zhai | Zendy; Quan Zhang | Zendy; Yue Chen | Zendy; Haibo Long | Zendy

Open Access

AOPPs Induce MCP-1 Expression by Increasing ROS-Mediated Activation of the NF-κB Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones

Author(s) -

Jiancheng Wang,

Yan Zhao,

SiJia Chen,

Jing Long,

Qianqian Jia,

Jiadai Zhai,

Quan Zhang,

Yue Chen,

Haibo Long

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356619

Subject(s) - iκbα , nf κb , reactive oxygen species , chemistry , monocyte , microbiology and biotechnology , western blot , oxidative stress , signal transduction , iκb kinase , thp1 cell line , proinflammatory cytokine , inflammation , biology , biochemistry , cell culture , immunology , genetics , gene

Monocyte chemoattractant protein-1 (MCP-1) plays an important role in extracellular matrix accumulation through macrophage recruitment and activation in the development and progression of diabetic nephropathy. Therefore, this study examined whether advanced oxidation protein products (AOPPs) are involved in nuclear factor-κB (NF-κB) activation and MCP-1 mRNA and protein expression in mesangial cells (MCs) and evaluated the effects of derivatives of sesquiterpene lactones (SLs) on AOPP-induced renal damage.

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