Modulation of HERG K+ Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation | Zendy

Liliang Shu | Zendy; Wanzhe Zhang | Zendy; Gang Su | Zendy; Jingchao Zhang | Zendy; Chao Liu | Zendy; Jing Xu | Zendy

Open Access

Modulation of HERG K<sup>+</sup> Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation

Author(s) -

Liliang Shu,

Wanzhe Zhang,

Gang Su,

Jingchao Zhang,

Chao Liu,

Jing Xu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356616

Subject(s) - herg , protein kinase c , patch clamp , protein kinase a , chemistry , intracellular , pharmacology , repolarization , reactive oxygen species , phosphorylation , potassium channel , microbiology and biotechnology , biochemistry , biophysics , medicine , biology , electrophysiology , receptor

Human ether-a-go-go-related gene (HERG) channel is the major molecular component of the native rapid delayed rectifier K(+) current (IKr) that is a crucial determinant of cardiac repolarization. Impairment of IKr/HERG function is commonly believed to be a mechanism causing long QT syndromes (LQTS), a lethal ventricular tachyarrhythmia. The cAMP-dependent protein kinase A (PKA) and PKC activities are markedly increased in some pathological conditions of the heart such as heart failure. This study was designed to investigate the effects of acute and chronic exposure to PKA or PKC activators and inhibitors on HERG channel activities and to provide insight into the mechanisms for the modulations.

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